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2024

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• Manohar P, Loh B, Nachimuthu R, Leptihn S. (2024) Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms. Scientific Reports. 14, 9354.

  doi: 10.1038/s41598-024-59444-2
   

• Manohar P, Loh B, Turner D, Tamizhselvi R, Mathankumar M, Elangovan N, Nachimuthu R, Leptihn S. (2024) In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. Frontiers in Microbiology. 15:1344962.

  doi: 10.3389/fmicb.2024.1344962

 

2023
 

• He J, Shi Q, Chen Z, Zhang W, Lan P, Xu Q, Hu H, Chen Q, Fan J, Jiang Y, Loh B, Leptihn S, Zou Q, Zhang J, Yu Y, Hua X. (2023) Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae. Drug Resist Updat 66:100891.

  doi: 10.1016/j.drup.2022.100891.

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2022

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• Manohar P, Loh B, Turner D, Tamizhselvi R, Mathankumar M, Elangovan N, Nachimuthu R, Leptihn S. (2022) In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. BioRxiv.

  doi: 10.1101/2022.10.12.512010
   

• Manohar P, Loganathan A, Nachimuthu R, Loh B, Ma L, Turner D, Leptihn S. (2022) Complete Genome Sequence of Pseudomonas Phage Motto. Microbiol Resour Announc. 11(11):e0074022.

  doi: 10.1128/mra.00740-22.
   

• Manohar P, Loh B, Ramesh N, and Leptihn S. (2022) Phage-antibiotic combinations to control Pseudomonas aeruginosa- Candida albicans two-species biofilms. BioRxiv.

  doi: 10.1101/2022.08.18.504394.
   

• Liu M, Tian Y, Zaki HEM, Ahmed T, Yao R, Yan C, Leptihn S, Loh B, Shahid MS, Wang F, Chen J, Li B. (2022) Phage Resistance Reduced the Pathogenicity of Xanthomonas oryzae pv. oryzae on Rice. Viruses. 14(8):1770.

  doi: 10.3390/v14081770.

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• Zhang L, Wang X, Hua X, Yu Y, Leptihn S, Loh B. (2022) Therapeutic evaluation of the Acinetobacter baumannii phage Phab24 for clinical use. Virus Res. 320:198889.

  doi: 10.1016/j.virusres.2022.198889.
   

• Ramesh N, Manohar P, Eniyan K, Archana L, Athira S, Loh B, Ma L, Leptihn S. (2022) A Lysozyme Murein Hydrolase with Broad-Spectrum Antibacterial Activity from Enterobacter Phage myPSH1140. Antimicrob Agents Chemother 66(9):e0050622.

  doi: 10.1128/aac.00506-22.
   

• Arumugam SN, Manohar P, Sukumaran S, Sadagopan S, Loh B, Leptihn S, Nachimuthu R (2022) Antibacterial efficacy of lytic phages against multidrug-resistant Pseudomonas aeruginosa infections in bacteraemia mice models. BMC Microbiol. 22(1):187.

  doi: 10.1186/s12866-022-02603-0.

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• Leptihn S, Loh B. (2022) Complexity, challenges and costs of implementing phage therapy. Future Microbiol 17:643-646.

  doi: 10.2217/fmb-2022-0054.

​

• Zhang L, Fu Y, Zhang L, Xu Q, He J, Leptihn S, Loh B, Toleman M, Chen Q, Liu L, Yu Y, and Hua X. (2022) Co-evolutionary adaptations of Acinetobacter baumannii and a clinical carbapenemase-encoding plasmid during carbapenem exposure. Evolutionary Applications 15(7):1045-1061.

  doi: 10.1111/eva.13441.

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• Manohar P, Loh B, Namasivayam E, Loganathan A, Nachimuthu R, Leptihn S. (2022) A multiwell-plate Caenorhabditis elegans assay for assessing the therapeutic potential of Bacteriophages against Clinical Pathogens. Microbiology Spectrum 10(1):e0139321.

  doi: 10.1128/spectrum.01393-21

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• Zhang M, Wang Y, Chen J, Hong X, Xu X, Wu Z, Ahmed T, Loh B, Leptihn S, Hassan S, Hassan MM, Sun G, Li B. (2022) Identification and Characterization of a New Type of Holin-Endolysin Lysis Cassette in Acidovorax oryzae Phage AP1. Viruses 14(2):167.

  doi: 10.3390/v14020167

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• Manohar P, Royam MM, Loh B, Bozdogan B, Nachimuthu R, Leptihn S. (2022) Synergistic Effects of Phage-Antibiotic Combinations against Citrobacter amalonaticus. ACS Infectious Diseases 8(1):59-65. doi: 10.1021/acsinfecdis.1c00117

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2021

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• Loh B, Wang X, Hua X, Luo J, Wen T, Zhang L, Ma L, Manohar P, Nachimuthu R, Grainge I, Yu Y, Leptihn S. (2021) Complete genomes of Bacteriophages Kaya, Guyu, Kopi and TehO that target clinical strains of Pseudomonas aeruginosa. Microbiology Resource Announcements 10(48):e0104321.

  doi: 10.1128/MRA.01043-21

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• Loh B, Zhang L, Hua X, Yu Y, Long M, Wang X, Manohar P, Nachimuthu R, Martins WMBS, Toleman MA, Leptihn S. (2021) Complete Genome of the Virulent Klebsiella pneumoniae Phage Geezett Infecting Multidrug-Resistant Clinical Strains. Microbiology Resource Announcements 10(48):e0068521.

  doi: 10.1128/MRA.00685-21

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• Wang X, Loh B, Altamirano FG, Yu Y, Hua X, Leptihn S. (2021) Colistin-phage combinations decrease antibiotic resistance in A. baumannii via changes in envelope architecture. Emerging Microbes & Infections 10(1):2205-2219.

  doi: 10.1080/22221751.2021.2002671

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• Loh B, Wang X, Hua X, Chook HW, Ma L, Zhang L, Manohar P, Jin Y, Leptihn S. (2021) Complete genome of the lytic bacteriophage Phab24 that infects clinical strains of the nosocomial pathogen Acinetobacter baumannii. Microbiology Resource Announcements 10(40) e00669-21.

  doi: 10.1128/MRA.00669-21

​

• Wu Z, Zhang Y, Xu X, Ahmed T, Yang Y, Loh B, Leptihn S, Yan C, Chen J, Li B. (2021) The holin-endolysin lysis system of the OP2-like phage infecting Xanthomonas oryzae pv. oryzae. Viruses 13, 1949.

  doi: 10.3390/v13101949

​

• Wang X, Loh B, Yu Y, Hua X, Leptihn S (2021) Phage resistance mechanisms increase colistin sensitivity in Acinetobacter baumannii. bioRxiv 2021.07.23.453473. 

  doi: 10.1101/2021.07.23.453473

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• Cai H, Zhu Y, Hu D, Li Y, Leptihn S, Loh B, Hua X, Yu Y (2021) Co-harboring of novel hybrid blaKPC−2 plasmid and ICE carrying Tn6203 in multidrug-resistant Pseudomonas aeruginosa. Frontiers in Microbiology 12:1682.

  doi: 10.3389/fmicb.2021.674974

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• Cui Z, Zhang Y, Kakar KU, Kong X, Li R, Loh B, Leptihn S, Li B (2021) Involvement of non-coding RNAs during infection of rice by Acidovorax oryzae. Environmental Microbiology Reports 13(4), 540-554.

  https://doi.org/10.1111/1758-2229.12982

​

• Wang X, Zhang M, Loh B, Leptihn S, Ahmed T, Li B (2021) A Novel NRPS Cluster, Acquired by Horizontal Gene Transfer from Algae, Regulates Siderophore Iron Metabolism in Burkholderia seminalis R456. International Journal of Biological Macromolecules 182:838-848.

  doi:10.1016/j.ijbiomac.2021.04.051

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• Das R, Kotra K, Singh P, Loh B, Leptihn S, Bajpai U (2021) Alternative Treatment Strategies for Secondary Bacterial and Fungal Infections Associated with COVID-19. Infectious Diseases & Therapy 1–25.

  doi: 10.1007/s40121-021-00559-8

​

• Feng T, Leptihn S, Dong K, Loh B, Zhang Y, Li M, Guo XK, Zelin Cui (2021) JD419, a Staphylococcus aureus phage with a unique morphology and broad host range. Frontiers in Microbiology 12:602902.

  doi: 10.3389/fmicb.2021.602902

​​

2020​
 

• Loh B*, Gondil VS*, Manohar P, Khan FM, Yang H, Leptihn S (2020) Encapsulation and Delivery of Therapeutic Phages. Applied and Environmental Microbiology  87:e01979-20. (Featured on the cover)

  doi: 10.1128/AEM.01979-20

​

• Loh B*, Chen J*, Manohar P, Yu Y, Hua X, Leptihn S (2020) A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. Frontiers in Microbiology 11: 3055.

  doi: 10.3389/fmicb.2020.579802

​

• Hua X, Xu Q, He J, Zhang D, Chen Q, Zhang L, Loh B, Leptihn S, Wen Y, Higgins P, Zhou Z, Yu Y (2020) The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China. International Journal of Medical Microbiology 310(8): 151464.

  doi: 10.1016/j.ijmm.2020.151464

​

• Fang J, Zhang L, He J, Zhao M, Loh B, Leptihn S, Yu Y, Hua X (2020) Plasmid dynamics of mcr-1-positive Salmonella spp. in a general hospital in China. Frontiers in Microbiology 11:3320.

  doi: 10.3389/fmicb.2020.604710

​

• Manohar P, Loh B, Leptihn S (2020) Will the overuse of Antibiotics during the Coronavirus pandemic accelerate Antimicrobial resistance? Infectious Microbes & Diseases 2(3):87-88.

  doi: 10.1097/IM9.0000000000000034

​

• Manohar P, Loh B, Nachimuthu R, Hua X, Welburn SC, Leptihn S (2020) Secondary Bacterial Infections in Patients with Viral Pneumonia. Frontiers in Medicine 7: 420.

  doi: 10.3389/fmed.2020.00420

​

• Manohar P*, Loh B*, Athira S, Nachimuthu R, Hua X, Welburn SC and Leptihn S (2020) Secondary Bacterial Infections During Pulmonary Viral Disease: Phage Therapeutics as Alternatives to Antibiotics? Frontiers in Microbiology 11: 1434.

  doi: 10.3389/fmicb.2020.01434

​

• Loh B and Leptihn S (2020) A call for a multidisciplinary future of Phage Therapy to combat multi-drug resistant bacterial infections. Infectious Microbes & Diseases 2(1),1-2.

  doi: 10.1097/IM9.0000000000000018

​​​

2019 - 2008

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• Loh B, Kuhn A, Leptihn S (2019) The fascinating biology behind phage display: Filamentous Phage Assembly. Molecular Microbiology 111(5), 1132-1138.
  ​

• Loh B, Haase M, Mueller L, Kuhn A, Leptihn S (2017) The transmembrane morphogenesis protein gp1 of filamentous phages contains Walker A and Walker B motifs essential for phage assembly. Viruses 9(4): 73.

  doi: 10.3390/v9040073

​

• Altrichter S, Haase M, Loh B, Kuhn A, Leptihn S (2017) Mechanism of the spontaneous and directional membrane insertion of a 2-transmembrane ion channel. ACS Chemical Biology 12(2): 380-388.

  doi: 10.1021/acschembio.6b01085

​

• Utturkar SM, Huber H, Leptihn S, Loh B, Brown SD, Stetter KO, Podar M (2016) Draft genome sequence of Pyrodictium occultum PL19, a marine hyperthermophilic species of Archaea that grows optimally at 105℃. Genome Announcement 4(1).

  doi: 10.1128/genomeA.00016-16

​

• Jonas S*, Christie M*, Peter D*, Bhandari D, Loh B, Huntzinger E, Weichenrieder O & Izaurralde E (2014) An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. Nature Structural & Molecular Biology 21(7): 599-608. doi: 10.1038/nsmb.2837
   

• Chen Y*, Boland A*, Kuzuoğlu-Öztürk D*, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E (2014) A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing. Molecular Cell 54(5): 737-50.

  doi: 10.1016/j.molcel.2014.03.034

​

• Loh B. (2014) The CCR4-NOT deadenylation complex functions in the Nonsense Mediated mRNA decay pathway. Eberhard Karls Universität Tübingen, PhD dissertation.
   

• Chang CT, Bercovich N, Loh B, Jonas S & Izaurralde E (2014) The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Research 42: 5217-5233.

  doi: 10.1093/nar/gku129

​

• Loh B, Jonas S & Izaurralde E (2013) The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes & Development 27: 2125-38.

  doi: 10.1101/gad.226951.113

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• Bawankar P, Loh B, Wohlbold L, Schmidt S & Izaurralde E (2013) NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biology 10: 228-244.

  doi: 10.4161/rna.23018

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• Vozzolo L, Loh B, Gane PJ, Tribak M, Zhou L, Anderson I, Nyakatura E, Jenner RG, Selwood D & Fassati A (2010) Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein. Journal of Biological Chemistry 285: 39314-28.

  doi: 10.1074/jbc.M110.155275

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• Loh B, Vozzolo L, Mok J, Lee C, Fitzmaurice R, Caddick S and Fassati A. (2009) Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides. Chemical Biology & Drug Design 75(5): 461-74.

  doi: 10.1111/j.1747-0285.2010.00956.x

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• Loh B, Wang XW, Bui THH, Luan XL, Ho B and Ding JL. (2008) SARM: A novel Toll-like receptor adaptor, is functionally conserved from arthropod to human. Molecular Immunology 45(6):1732-42.

  doi: 10.1016/j.molimm.2007.09.030